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More →OpenAI Buys Orchestra Bio to Put AI Agents in Charge of Drug Development Grunt Work
OpenAI has bought Orchestra Bio, a San Francisco startup whose AI agents help drug companies keep sprawling development programs on schedule, the ChatGPT maker <a href="https://openai.com/index/openai-to-acquire-orchestra-bio/" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>announced Tuesday</a>. “Our goal is to help scientists make discoveries and manage the work needed to turn them into treatments that reach patients sooner,” OpenAI said in the announcement. Orchestra’s team and platform will be folded into <a href="https://openai.com/rosalind/" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>Rosalind</a>, OpenAI’s family of AI models and tools for biologists and chemists. The financial terms were not disclosed. Getting a new medicine from first idea to U.S. approval takes time—up to 15 years according to OpenAI. Every month shaved off that timeline is a month earlier that a new treatment can reach the people waiting for it, and a month earlier that the company can generate cash. The process is also absurdly expensive: bringing one approved drug to market can cost more than <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12668846/" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>$2.6 billion</a>, and <a href="https://arxiv.org/pdf/2106.05386" target="_blank" class="sc-adb616fe-0 dJryYS" rel="nofollow">fewer than 10%</a> of candidates that enter human testing ever make it to pharmacy shelves. Beyond the science itself, OpenAI says drug teams have to coordinate work across internal departments and outside partners, often relying on systems that don’t talk to each other. Those partners usually include contract research organizations, the outside labs hired to run studies, and contract manufacturers that produce the experimental drug. Orchestra’s AI agents—software that can watch over tasks and flag problems on its own—work out which activities and deadlines take the hit, gather the relevant information and compare ways to respond, while scientists and program leaders make the final call. Founded in the fall of 2022, Orchestra raised its <a href="https://jobs.8vc.com/companies/orchestra/jobs/28818089-senior-software-engineer" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>seed round</a> from Andreessen Horowitz, Definition Capital, Insight Partners, and 8VC, and about $20 million in total, according to <a href="https://www.caplight.com/company/orchestra-bio" target="_blank" class="sc-adb616fe-0 dJryYS" rel="nofollow">Caplight data</a>. The company should not be confused with Orchestra BioMed, an unrelated Nasdaq-listed medical device maker that trades under the ticker OBIO. In April, OpenAI launched <a href="https://decrypt.co/364783/openai-gpt-rosalind-drug-discovery-life-sciences-model" target="_blank" class="sc-adb616fe-0 dJryYS" rel="nofollow">GPT-Rosalind</a>, a model built specifically for biology and dru
OpenAI issued a statement regarding a critical vulnerability in PHP software and pledged $1 billion in subsidies.
CoinWorld news, Cailian Press, October 21 (Xinhua) — OpenAI issued a statement regarding a critical vulnerability discovered in PHP software, noting that given the severity of the vulnerability and the widespread use of PHP, it is one of the most impactful vulnerabilities in recent times. OpenAI pledged to provide $1 billion in subsidized access credits through its "Daybreak for Frontline Defenders" program to support defenders.
OpenAI: Recently issued a statement regarding a PHP security vulnerability.
CoinWorld news: OpenAI has recently expressed the following views in succession: First, regarding the PHP security vulnerability issue, OpenAI stated that frontier AI models discovered these vulnerabilities before attackers did. Second, OpenAI has committed $1 billion to provide subsidized Daybreak access to frontline cybersecurity defenders through the Daybreak project.
U.S. EIA crude oil inventories fell to the lowest level since 1982.
CoinWorld news, according to Gelonhui, U.S. EIA strategic petroleum reserve inventories for the week ending October 16 fell to their lowest level since October 15, 1982. Meanwhile, domestic crude oil production posted its largest decline since January 30, 2026, and output also hit its lowest since January 30, 2026. In addition, commercial crude oil inventories excluding the strategic reserve also fell to their lowest since July 31, 2026, while the decline in EIA gasoline inventories was the largest since May 8, 2026.
EIA report: U.S. crude oil exports and production both decline
According to a report from Gelonghui cited by Bijie, the EIA report shows that in the week of October 16, U.S. crude oil exports decreased by 1.128 million barrels to 3.442 million barrels per day, while domestic crude oil production fell by 410,000 barrels to 13.269 million barrels per day. In addition, commercial crude oil inventories, excluding the Strategic Petroleum Reserve, decreased by 3.060 million barrels, a decline of 0.74%, bringing total inventories to 413 million barrels. The four-week average supply of U.S. crude oil products was 21.122 million barrels per day, up 3.16% compared with the same period last year. Strategic Petroleum Reserve (SPR) inventories decreased by 300,000 barrels to 282.7 million barrels, a decline of 0.11%. Commercial crude oil imports were 5.758 million barrels per day, down 291,000 barrels from the previous week.
The world's richest person integrates SpaceX and Tesla for the AI singularity.
According to CoinWorld news, the world's richest person is preparing for the "AI singularity" and plans to integrate SpaceX and Tesla into a single company covering rockets, satellites, internet services, chatbots, social media, robotics, and automobiles.
The U.S. government is lending 315,000 barrels of fuel to counter rising oil prices.
According to CoinWorld news, the administration of U.S. President Trump is borrowing 315,000 barrels of fuel (out of a total of 1 million barrels) from the Northeast Home Heating Oil Reserve to address a sharp rise in fuel prices. Data from the American Automobile Association (AAA) shows that the average price of diesel is about $6.32 per gallon. Releasing several hundred thousand barrels of crude oil from the reserve is unlikely to have a significant impact on prices. The U.S. Department of Energy plans to complete delivery by November 13, and Energy Secretary Chris Wright called the move a temporary measure to address a temporary supply disruption.
ChatGPT upgrades SpaceX ($SPCX) stock rating from Sell to Buy.
According to CoinWorld news, ChatGPT recently upgraded its rating on SpaceX ($SPCX) stock from sell to buy, with analysts believing the stock has investment value.
The 4-hour trading volume ratio of BTC contracts to spot is 8.36.
CoinWorld data: Over the most recent 4 complete hours, BTCUSDT perpetual contract trading volume was 8.36 times spot trading volume. Compared with the same-caliber snapshot 24 hours earlier, it rose by 1.8142; compared with the same-caliber snapshot 7 days earlier, it fell by 0.6735.
U.S. EIA crude oil inventories for the week ending October 16: -3.06 million barrels.
BiJie Network data: U.S. EIA crude oil inventories for the week ending October 16 fell by 3.06 million barrels, compared with expectations of a 820,000-barrel decline and a previous value of an 8.557-million-barrel decrease.