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More →OpenAI Buys Orchestra Bio to Put AI Agents in Charge of Drug Development Grunt Work
OpenAI has bought Orchestra Bio, a San Francisco startup whose AI agents help drug companies keep sprawling development programs on schedule, the ChatGPT maker <a href="https://openai.com/index/openai-to-acquire-orchestra-bio/" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>announced Tuesday</a>. “Our goal is to help scientists make discoveries and manage the work needed to turn them into treatments that reach patients sooner,” OpenAI said in the announcement. Orchestra’s team and platform will be folded into <a href="https://openai.com/rosalind/" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>Rosalind</a>, OpenAI’s family of AI models and tools for biologists and chemists. The financial terms were not disclosed. Getting a new medicine from first idea to U.S. approval takes time—up to 15 years according to OpenAI. Every month shaved off that timeline is a month earlier that a new treatment can reach the people waiting for it, and a month earlier that the company can generate cash. The process is also absurdly expensive: bringing one approved drug to market can cost more than <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12668846/" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>$2.6 billion</a>, and <a href="https://arxiv.org/pdf/2106.05386" target="_blank" class="sc-adb616fe-0 dJryYS" rel="nofollow">fewer than 10%</a> of candidates that enter human testing ever make it to pharmacy shelves. Beyond the science itself, OpenAI says drug teams have to coordinate work across internal departments and outside partners, often relying on systems that don’t talk to each other. Those partners usually include contract research organizations, the outside labs hired to run studies, and contract manufacturers that produce the experimental drug. Orchestra’s AI agents—software that can watch over tasks and flag problems on its own—work out which activities and deadlines take the hit, gather the relevant information and compare ways to respond, while scientists and program leaders make the final call. Founded in the fall of 2022, Orchestra raised its <a href="https://jobs.8vc.com/companies/orchestra/jobs/28818089-senior-software-engineer" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>seed round</a> from Andreessen Horowitz, Definition Capital, Insight Partners, and 8VC, and about $20 million in total, according to <a href="https://www.caplight.com/company/orchestra-bio" target="_blank" class="sc-adb616fe-0 dJryYS" rel="nofollow">Caplight data</a>. The company should not be confused with Orchestra BioMed, an unrelated Nasdaq-listed medical device maker that trades under the ticker OBIO. In April, OpenAI launched <a href="https://decrypt.co/364783/openai-gpt-rosalind-drug-discovery-life-sciences-model" target="_blank" class="sc-adb616fe-0 dJryYS" rel="nofollow">GPT-Rosalind</a>, a model built specifically for biology and dru
OpenAI reviews PHP vulnerability incident: two months of secret coordination, but leaked early by a forum
Coin World News: OpenAI published a retrospective on the secret repair operation behind the PHP vulnerability incident. Security firms Calif and Wiz separately used GPT-5.6 SOL and Gemini 4 Argon to discover serious vulnerabilities in PHP. These issues had lain hidden in PHP's underlying code for more than a decade, and attackers could take control of servers hosting affected websites. OpenAI led the coordination among PHP maintainers, Wiz, Cloudflare, and other organizations, preparing patches and defensive measures, and communicated with the White House and U.S. cybersecurity agencies. The fix involved nearly 200 files and more than 10,000 lines of code. The vulnerability was originally scheduled to be disclosed on October 22, but on the 20th someone leaked the information early on the Hacker News forum, forcing the PHP team to issue an alert ahead of schedule and move the patch release date up by one day. Cloudflare confirmed it observed early attack attempts, and some government websites proactively went offline to avoid risk. On October 21, PHP officially released the fixed version, and websites needed to upgrade on their own. OpenAI called this period the "defender's window." Wiz research shows that AI models have significantly shortened the development time for complex vulnerability exploitation methods.
Bitfinex expects Bitcoin to remain range-bound between $81,300 and $84,400 ahead of the Federal Reserve's interest rate decision.
Bitfinex data: Bitfinex expects Bitcoin to trade in a range of $81,300 to $84,400 ahead of the Federal Reserve's FOMC interest rate decision on October 28. On October 19, spot Bitcoin ETFs saw net inflows of $526.7 million, with BTC price fluctuating between $81,724 and $83,470, below the average cost basis of $84,333 for ETF investors. Open interest in futures on major exchanges rebounded 4.2% to 645,410 BTC. Options with a notional open interest of $1.23 billion expire on October 23, with the max pain point at approximately $82,000. Monthly options worth $11.2 billion expire on October 30, with the max pain point at $76,000. On-chain data shows that approximately 145,000 BTC were added at the $82,224 cost basis range, while approximately 62,000 BTC were removed from the $80,353 cost basis range. The SOPR for short-term holders is approximately 1.003, and profitable supply accounts for about 70%.
eMudhra private key leak puts global security teams on high alert
According to CoinWorld news, the private keys of eight certificates belonging to eMudhra, India's largest digital trust service provider, have been leaked, and attackers could use these keys to forge trusted certificates. Security teams around the world have been placed on high alert. eMudhra has revoked all eight certificates, and Firefox, Apple, and Microsoft have also rolled out protective measures, while some software is still awaiting updates.
OpenAI launches security tools and offers $1 billion in AI subsidies
CoinWorld news: OpenAI launches security tools amid a global PHP security crisis and offers $1 billion in AI access subsidies. Under its "Patch the Planet" initiative, OpenAI has released a PHP vulnerability scanning tool and plans to launch Codex capabilities to help websites identify and fix security risks. The company worked with PHP developers Wiz and Cloudflare for two months to prepare protective measures, and warned that AI could also help hackers develop exploits faster.
The Miden chain connects to the broader crypto ecosystem through Agglayer.
CoinWorld news: Miden is the first non-EVM chain, connected to the broader crypto ecosystem through Agglayer. Miden is a privacy-centric, Turing-complete smart contract blockchain, akin to a Zcash-style Ethereum smart contract. Miden brings general-purpose programmability to a privacy-first blockchain, and Agglayer now connects not only EVM chains but also fundamentally different blockchain architectures.
Kalshi partners with Bitgo to support crypto asset collateralized lending for futures margin.
Coin World news: Kalshi has partnered with Bitgo to allow Kalshi Prime clients to borrow against their custodied crypto assets as collateral and use the loan proceeds as margin for perpetual futures trading. The arrangement uses a tripartite collateral management structure, with loans provided by Kalshi Katalyst and collateral assets held at Bitgo Bank & Trust. Eligible collateral assets include Bitcoin, Ethereum, and stablecoins compliant with the Genius Act. Kalshi Prime CEO Jeff Bandman said the arrangement allows clients to participate in trading without having to exit their crypto asset positions.
Jensen Huang unveils AI "prefab factory" DSX POD, deployable and operational in as fast as 14 days
CoinWorld news, NVIDIA CEO Jensen Huang announced at the GTC conference held in Berlin, Germany, the launch of the modular AI factory reference design DSX POD, which is planned to be delivered globally through partners in early 2027. The solution moves work such as computing, networking, cabling, rack power supply, liquid cooling pipe installation, and functional verification to the factory in advance. DSX POD can shorten the infrastructure deployment cycle from about 6 months under the traditional approach to as short as 14 days. NVIDIA stated that AI factories can create value only when they begin generating tokens, aiming to shorten the time from on-site readiness of infrastructure to the start of running production-grade AI workloads, enabling operators to generate revenue earlier.
US spot Bitcoin ETFs saw a net outflow of 403 BTC, while Ethereum ETFs saw a net outflow of 12,700 ETH.
BiJie Network data: Today, U.S. Bitcoin ETFs saw a net outflow of 403 BTC, while over the past 7 days they saw a net inflow of 2,528 BTC. Ethereum ETFs saw a net outflow of 12,700 ETH today, and a net outflow of 155,100 ETH over the past 7 days.
BTC is oscillating in the $80,000 to $87,000 range.
CoinWorld data: BTC is currently in a trading range between $80,000 and $87,000. Buyers below are replenishing buy orders at ETF and treasury cost bases, while the upside is concentrated with major buyers' break-even points, major sell orders, and the largest liquidation clusters. This week's on-chain data will cover ETF fund flows, MSCI, and altcoin-related content.