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More →OpenAI Buys Orchestra Bio to Put AI Agents in Charge of Drug Development Grunt Work
OpenAI has bought Orchestra Bio, a San Francisco startup whose AI agents help drug companies keep sprawling development programs on schedule, the ChatGPT maker <a href="https://openai.com/index/openai-to-acquire-orchestra-bio/" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>announced Tuesday</a>. “Our goal is to help scientists make discoveries and manage the work needed to turn them into treatments that reach patients sooner,” OpenAI said in the announcement. Orchestra’s team and platform will be folded into <a href="https://openai.com/rosalind/" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>Rosalind</a>, OpenAI’s family of AI models and tools for biologists and chemists. The financial terms were not disclosed. Getting a new medicine from first idea to U.S. approval takes time—up to 15 years according to OpenAI. Every month shaved off that timeline is a month earlier that a new treatment can reach the people waiting for it, and a month earlier that the company can generate cash. The process is also absurdly expensive: bringing one approved drug to market can cost more than <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12668846/" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>$2.6 billion</a>, and <a href="https://arxiv.org/pdf/2106.05386" target="_blank" class="sc-adb616fe-0 dJryYS" rel="nofollow">fewer than 10%</a> of candidates that enter human testing ever make it to pharmacy shelves. Beyond the science itself, OpenAI says drug teams have to coordinate work across internal departments and outside partners, often relying on systems that don’t talk to each other. Those partners usually include contract research organizations, the outside labs hired to run studies, and contract manufacturers that produce the experimental drug. Orchestra’s AI agents—software that can watch over tasks and flag problems on its own—work out which activities and deadlines take the hit, gather the relevant information and compare ways to respond, while scientists and program leaders make the final call. Founded in the fall of 2022, Orchestra raised its <a href="https://jobs.8vc.com/companies/orchestra/jobs/28818089-senior-software-engineer" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>seed round</a> from Andreessen Horowitz, Definition Capital, Insight Partners, and 8VC, and about $20 million in total, according to <a href="https://www.caplight.com/company/orchestra-bio" target="_blank" class="sc-adb616fe-0 dJryYS" rel="nofollow">Caplight data</a>. The company should not be confused with Orchestra BioMed, an unrelated Nasdaq-listed medical device maker that trades under the ticker OBIO. In April, OpenAI launched <a href="https://decrypt.co/364783/openai-gpt-rosalind-drug-discovery-life-sciences-model" target="_blank" class="sc-adb616fe-0 dJryYS" rel="nofollow">GPT-Rosalind</a>, a model built specifically for biology and dru
U.S. EIA crude oil inventories fell by 3.06 million barrels.
CoinWorld news: U.S. EIA crude oil inventories for the week ending October 16 fell by 3.06 million barrels, compared with expectations of a 820,000-barrel decline and a previous decrease of 8.557 million barrels.
U.S. EIA crude oil imports: 837,000 barrels
According to CoinWorld news, the U.S. EIA crude oil imports for the week ending October 16 were 837,000 barrels, compared with the previous value of -596,000 barrels.
BTC突破84000 USDT，24H涨幅1.29%
CoinWorld data: OKX market data shows BTC is currently at 84,003 USDT, with a 24-hour gain of 1.29%.
Crypto market maker GSR adjusts weightings for Bitcoin, Solana, and Ethereum.
CoinWorld data: Crypto market maker GSR released its latest core3 model portfolio weekly report on October 21, lowering Bitcoin's weight by about 2.5 percentage points to 40.5%, raising Solana to 23.5%, and keeping Ethereum unchanged at 36.0%. The report said that the crypto market stabilized last week, with BTC, ETH, and SOL rising 1.4%, 0.7%, and 2.1%, respectively, but all three still posted monthly declines, with ETH and SOL falling more than 9%. 30-day volatility dropped sharply, with Bitcoin, Ethereum, and Solana falling 18.4%, 16.7%, and 28.5%, respectively, approaching historic lows. 30-day trading volume fell 39% month-on-month to 53%, while Ethereum's trading volume rose 48% during the week. The adjustment aims to increase exposure to Solana, which had the strongest performance last week and the largest volatility compression.
Binance announces a large-scale XRP airdrop campaign with total rewards of 600,000 XRP.
CoinWorld news: Binance has announced that it will launch a large-scale XRP airdrop campaign on October 23, planning to give away a total of 600,000 XRP to users. Users need to hold Ripple's RLUUSD stablecoin on the platform, with a minimum balance of only 0.01 RLUUSD. The airdrop will take place weekly, with the first airdrop expected on October 30. Binance stated that users do not need to hold XRP to participate, and rewards will be calculated based on eligible RLUUSD balances. The campaign will continue until the 600,000 XRP reward pool is exhausted.
Glassnode: Bitcoin price faces critical support near $87,000
CoinWorld data: Glassnode reports that Binance's bid inquiries and the largest liquidation cluster are located near $87,000. Top buyers are still capping Bitcoin's price around the same level. If the daily close is above that level, accompanied by ETF inflows, it will show that buyers are absorbing supply. For more content, please follow this week's on-chain weekly report.
The U.S. 10-year Treasury yield is at 5.15%.
CoinWorld US stock market data: The latest daily reading of the US 10-year Treasury yield is 5.15%. Compared with the same-caliber snapshot 24 hours ago, it is up 0.06 percentage points; compared with the same-caliber snapshot 7 days ago, it is down 0.09 percentage points.
70% of websites worldwide face security risks as AI researchers discover php2shell vulnerability.
Cointime news: AI researchers have discovered php2shell, a severe security vulnerability that could put as many as 70% of websites worldwide at risk. The flaw could allow hackers to hijack unpatched servers, steal sensitive information, and launch attacks on website visitors. PHP is widely used in WordPress, government portals, and e-commerce sites. The vulnerability, rated as high as 9.2/10 in two reports, could allow attackers to remotely execute malicious code without authentication. The latest developments include: Finland shutting down national internet services in response to the security flaw; the Dutch National Cyber Security Centre taking its website offline; and France temporarily closing provincial websites pending security fixes. Cloudflare reported that early attacks have already occurred and said protections are now live. Due to the leak of vulnerability details, an emergency patch was released ahead of schedule. EU cybersecurity officials are calling for immediate patching and advise operators to take vulnerable websites offline if fixes cannot be applied. The biggest concern is that AI could accelerate the development of exploits, allowing hackers to weaponize these vulnerabilities before millions of websites can be protected.
Grayscale allows investors to deliver Bitcoin in exchange for spot ETF shares.
Cointime news: Grayscale allows investors to obtain shares of its spot ETF by delivering Bitcoin.