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More →OpenAI Buys Orchestra Bio to Put AI Agents in Charge of Drug Development Grunt Work
OpenAI has bought Orchestra Bio, a San Francisco startup whose AI agents help drug companies keep sprawling development programs on schedule, the ChatGPT maker <a href="https://openai.com/index/openai-to-acquire-orchestra-bio/" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>announced Tuesday</a>. “Our goal is to help scientists make discoveries and manage the work needed to turn them into treatments that reach patients sooner,” OpenAI said in the announcement. Orchestra’s team and platform will be folded into <a href="https://openai.com/rosalind/" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>Rosalind</a>, OpenAI’s family of AI models and tools for biologists and chemists. The financial terms were not disclosed. Getting a new medicine from first idea to U.S. approval takes time—up to 15 years according to OpenAI. Every month shaved off that timeline is a month earlier that a new treatment can reach the people waiting for it, and a month earlier that the company can generate cash. The process is also absurdly expensive: bringing one approved drug to market can cost more than <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12668846/" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>$2.6 billion</a>, and <a href="https://arxiv.org/pdf/2106.05386" target="_blank" class="sc-adb616fe-0 dJryYS" rel="nofollow">fewer than 10%</a> of candidates that enter human testing ever make it to pharmacy shelves. Beyond the science itself, OpenAI says drug teams have to coordinate work across internal departments and outside partners, often relying on systems that don’t talk to each other. Those partners usually include contract research organizations, the outside labs hired to run studies, and contract manufacturers that produce the experimental drug. Orchestra’s AI agents—software that can watch over tasks and flag problems on its own—work out which activities and deadlines take the hit, gather the relevant information and compare ways to respond, while scientists and program leaders make the final call. Founded in the fall of 2022, Orchestra raised its <a href="https://jobs.8vc.com/companies/orchestra/jobs/28818089-senior-software-engineer" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>seed round</a> from Andreessen Horowitz, Definition Capital, Insight Partners, and 8VC, and about $20 million in total, according to <a href="https://www.caplight.com/company/orchestra-bio" target="_blank" class="sc-adb616fe-0 dJryYS" rel="nofollow">Caplight data</a>. The company should not be confused with Orchestra BioMed, an unrelated Nasdaq-listed medical device maker that trades under the ticker OBIO. In April, OpenAI launched <a href="https://decrypt.co/364783/openai-gpt-rosalind-drug-discovery-life-sciences-model" target="_blank" class="sc-adb616fe-0 dJryYS" rel="nofollow">GPT-Rosalind</a>, a model built specifically for biology and dru
Fidelity: Preferred stock helped the company purchase nearly 136,000 bitcoins.
Fidelity said that preferred stock, as a bond-like investment that never matures, helped the company purchase nearly 136,000 bitcoins.
Three quarters after the NEAR halving, the staking rate remains at 46%.
CoinWorld data: A Bitwise report shows that three quarters after NEAR's supply reduction, the staking rate remains at 46%, with a total of 596 million tokens staked, worth approximately $3 billion, and an average yield of 4.87%.
The Saudi-led coalition: intercepted and destroyed a drone flying toward the eastern region.
Saudi-led coalition: intercepted and destroyed a drone flying toward the eastern region.
Bitwise: NEAR staking ratio remains at 46%
CoinWorld data: According to Cointelegraph, Bitwise data shows that NEAR's staking ratio has remained at 46% three quarters after the issuance halving, with 596 million tokens currently staked, worth approximately $3 billion, and an average staking yield of 4.87%.
BTC, ETH, and SOL derivatives open interest grows as prices recover.
According to data from Bijie.com: As cryptocurrency prices recover, the derivatives open interest for BTC, ETH, and SOL has reached $23.4 billion, $15.5 billion, and $2.7 billion, respectively. Among them, ETH has shown continuous growth since August, SOL has been highly volatile, while BTC remains below its spring high.
Kuwait Petroleum Corporation CEO: Crude oil exports have returned to pre-war levels.
CoinWorld news: The CEO of Kuwait Petroleum Corporation said that customers have already traveled to the Gulf region to collect cargo, and crude oil exports have recovered to pre-war levels.
Kuwait Petroleum Corporation CEO: Crude oil exports have returned to pre-war levels.
CoinWorld news: The CEO of Kuwait Petroleum Corporation said that customers have already traveled to the Gulf region to collect cargo, and crude oil exports have recovered to pre-war levels.
SpaceX bonds fall as market worries further debt issuance will worsen credit risk metrics
Coin World news, Cailian Press, October 22 - SpaceX bonds fell on Wednesday after the company reported results that beat analyst expectations but also said it is investing heavily, hinting at possible further debt issuance in the future. The risk premium on the aerospace and artificial intelligence (AI) company rose, and its credit derivative spreads had already widened earlier this week. As of 12:35 p.m. New York time, the spread on SpaceX's 6.6% coupon bonds maturing in 2046 widened by 0.09 percentage points to 2.64 percentage points.
Houthi armed forces: Saudi fighter jets struck the capital Sanaa
Houthi forces: In the past 24 hours, Saudi fighter jets carried out 62 airstrikes on the capital Sanaa and the provinces of Marib, Saada, Lahj, and Taiz, targeting civilian facilities. Since the escalation of their offensive against us on July 13 last year, the total number of airstrikes and missile attacks launched by the Saudi aggressor forces over 100 days has reached 2,855.